Estudos e Pesquisas
O Laboratório de Neurociências e Comportamento foi fundado no ano de 2011 pela Prof.ª Dr.ª Juliana Sartori Bonini, a qual hoje é Presidente da Associação de Estudos, Pesquisas e Auxílio às Pessoas com Alzheimer (AEPAPA), de Guarapuava/PR.
Desde sua fundação, foram publicados mais de:
– 80 artigos nacionais e internacionais;
– 34 trabalhos em eventos de cunho técnico-acadêmico e científico de cunho nacional e internacional.
Além disso, desde 2011, foram realizados mais de 78 orientações em Trabalhos de Conclusão de Curso (TCC) e em Projetos de Iniciação Científica, 27 orientações em Dissertações de Mestrado, 9 Teses de Doutorado e 4 de Pós-Doutorado.
Desde sua fundação, já passaram pelo Laboratório mais de 110 alunos e pesquisadores colaboradores, estando hoje mais de 15 projetos de pesquisa ativos em fase de desenvolvimento.
O objetivo geral que norteia a realização das pesquisas científicas junto ao Laboratório de Neurociências e Comportamento está na busca de métodos investigativos que auxiliem no rastreio e no manejo da Doença de Alzheimer, assim como voltado à outras de pesquisas atualmente existentes, as quais relacionam-se com a avaliação e intervenção neuropsicomotora e de obtenção de modelos alternativos para o tratamento de infecções e de outras comorbidades que tendem a afetar a saúde da população, trazendo avanços nas diferentes áreas das ciências da saúde, contribuindo para a melhora da saúde global dos indivíduos portadores de doenças e agravos crônicos, estando entre eles as doenças neurodegenerativas, como é o caso do Alzheimer.
Pesquisas Realizadas no Laboratório de Neurociências e Comportamento
2012
Avaliação do risco de disfagia, estado nutricional e ingestão calórica em idosos com Alzheimer
http://old.scielo.br/pdf/rlae/v22n2/pt_0104-1169-rlae-22-02-00317.pdf
D1/D5 dopamine receptors modulate spatial memory formation – https://www.sciencedirect.com/science/article/pii/S1074742712000068?via%3Dihub
Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation – https://www.sciencedirect.com/science/article/pii/S1074742711001584?via%3Dihub
2013
Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631664/
Prenatal stress produces social behavior deficits and alters the number of oxytocin and vasopressin neurons in adult rats –
https://link.springer.com/article/10.1007/s11064-013-1049-5
2014
AVALIAÇÃO DO EFEITO DA CURCUMINA SOBRE A TOXICIDADE DA ANFOTERICINA B –http://tede.unicentro.br:8080/jspui/bitstream/jspui/1740/2/disserta%c3%a7%c3%a3o%20Ketlyn%20Simone%20Vonick.pdf
Evaluation of dysphagia risk, nutritional status and caloric intake in elderly patients with Alzheimer’s – https://www.scielo.br/j/rlae/a/mkYzj6c3wC63Xgs3r7574Tf/?format=pdf&lang=pt
Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: A crosssectional study – https://200.145.71.41/index.php/ojs/article/view/132/130.
Psychophysiological, cognitive and behavioral aspects of malnutrition in Alzheimer’s disease: a review – http://seer.upf.br/index.php/rbceh/article/view/4432/pdf.
Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: A cross-sectional study – https://www.researchgate.net/publication/271078009_Nutritional_status_and_food_intake_of_Brazilian_patients_at_various_stages_of_Alzheimer’s_disease_A_cross-sectional_study.
Estado nutricional e consumo alimentar de pacientes brasileiros em diferentes estágios da doença de alzheimer: um estudo transversal / Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: a cross-sectional study – http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/132/130.
2014
AVALIAÇÃO DO EFEITO DA CURCUMINA SOBRE A TOXICIDADE DA ANFOTERICINA B –http://tede.unicentro.br:8080/jspui/bitstream/jspui/1740/2/disserta%c3%a7%c3%a3o%20Ketlyn%20Simone%20Vonick.pdf
Evaluation of dysphagia risk, nutritional status and caloric intake in elderly patients with Alzheimer’s – https://www.scielo.br/j/rlae/a/mkYzj6c3wC63Xgs3r7574Tf/?format=pdf&lang=pt
Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: A crosssectional study – https://200.145.71.41/index.php/ojs/article/view/132/130.
Psychophysiological, cognitive and behavioral aspects of malnutrition in Alzheimer’s disease: a review – http://seer.upf.br/index.php/rbceh/article/view/4432/pdf.
Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: A cross-sectional study – https://www.researchgate.net/publication/271078009_Nutritional_status_and_food_intake_of_Brazilian_patients_at_various_stages_of_Alzheimer’s_disease_A_cross-sectional_study.
Estado nutricional e consumo alimentar de pacientes brasileiros em diferentes estágios da doença de alzheimer: um estudo transversal / Nutritional status and food intake of Brazilian patients at various stages of Alzheimer’s disease: a cross-sectional study – http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/132/130.
2015
Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease
https://link.springer.com/article/10.1007/s00406-015-0665-2
Anxiolytic properties of Melissa officinalis and associated mechanisms of action: A review of the literature
https://www.researchgate.net/publication/272508674_Anxiolytic_properties_of_Melissa_officinalis_and_associated_mechanisms_of_action_A_review_of_the_literature7
Ginkgo bilobaL.: Phytochemical components and antioxidant activity
https://academicjournals.org/journal/AJPP/article-full-text/F54F7FF55634
Evaluation of curcumin toxicity in rats through biochemical and hematological parameters
https://academicjournals.org/journal/AJPP/article-full-text/5C79A7154809
2016
Incidence of polypharmacy in Alzheimer’s disease elderly patients from Guarapuava City (Paraná, Brazil) https://108.178.4.83/journal/AJPP/article-full-text/0C96E9E58409
Dificuldades na terapia antifúngica com anfotericina B e a busca contínua por novas formulações: uma revisão de literatura – https://www.researchgate.net/publication/305516436_Difficulties_in_antifungal_therapy_with_amphotericin_B_and_the_continuous_search_for_new_formulations_A_literature_review
2017
The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease
https://link.springer.com/article/10.1007/s12011-017-1042-y
Socio-demographic profile of individuals who received care from a Brazilian out-patient oncology clinic between 2010 and 2011.
https://doi.org/10.5897/JPHE2016.0893
Polypharmacy in Alzheimer’s disease patients in Brazil: Guidance for pharmaceutical assistance
https://f1000researchdata.s3.amazonaws.com/manuscripts/13908/9c2fd282-2ffa-49e0-8f2c-df46b8e4aa94_12835_-_juliana_bonini.pdf?doi=10.12688/f1000research.12835.1&numberOfBrowsableCollections=74&numberOfBrowsableInstitutionalCollections=4&numberOfBrowsableGateways=48
Aplicação Forense do Iodeto de Potássio: Um Novo Método Colorimétrico para Identificação de Resíduos de Disparos de Armas de Fogo
https://www.bjfs.org/forensicjournal/edicoes?volume=7&numero=1&artigo=291
Funcionalidade na doença de Alzheimer leve, moderada e grave: um estudo transversal
https://www.revistas.usp.br/actafisiatrica/article/view/153634/150064
Potential biomarkers for alzheimer’s disease screened in a small Brazilian population
https://medcraveonline.com/HPMIJ/HPMIJ-01-00022.pdf
Funcionalidade na doença de Alzheimer leve, moderada e grave: um estudo transversal / Functionality on mild, moderate and severe Alzheimer’s disease: a cros-sectional study
https://www.revistas.usp.br/actafisiatrica/article/view/153634
Avaliação das condições de saúde dos idosos e cuidadores de pacientes com demência de alzheimer
https://www.mastereditora.com.br/periodico/20170502_235953.pdf
2018
Depression, quality of life and cortisol: a cross-sectional study o0f caregivers of patients with Alzheimer’s disease
https://f1000researchdata.s3.amazonaws.com/manuscripts/15713/6d521c28-a672-439f-9ddf-6f01305f784b_14435_-_emanuela_bernardi.pdf?doi=10.12688/f1000research.14435.1&numberOfBrowsableCollections=74&numberOfBrowsableInstitutionalCollections=4&numberOfBrowsableGateways=48
Nutritional status, survival and mortality in Alzheimer patients – a cross-sectional study
https://f1000researchdata.s3.amazonaws.com/manuscripts/14080/ee00a7af-7884-4bf9-bff2-c80fd2f42168_12984_-_elizama_gregorio.pdf?doi=10.12688/f1000research.12984.1&numberOfBrowsableCollections=74&numberOfBrowsableInstitutionalCollections=4&numberOfBrowsableGateways=48
Adequacy of food consumption in elderly Alzheimer’s disease in a community of Southern Brazil: a Cross-sectional study
https://f1000researchdata.s3.amazonaws.com/manuscripts/15038/19b6581c-f7da-477b-823d-a59f95df8727_13835_-_glaucia_renee_hilgemberg.pdf?doi=10.12688/f1000research.13835.1&numberOfBrowsableCollections=74&numberOfBrowsableInstitutionalCollections=4&numberOfBrowsableGateways=48
Nutritional evaluation of geriatric patients with Alzheimer’s disease in Southern Brazil: case-control study
https://www.nutricionhospitalaria.org/articles/01626/show
Ethyl acetate fraction of Cymbopogon citratus as a potential source of antioxidant compounds
https://pubs.rsc.org/en/content/articlelanding/2018/NJ/C7NJ04352J
2019
Nutritional and hematological factors associated with the progression of Alzheimer’s disease: a cohort study
https://www.scielo.br/j/ramb/a/cBVLBXznN6nTMMDzvHQT8fs/?format=pdf&lang=en
Aminolevulinate dehydratase and glutathione peroxidase activity in alzheimer’s disease: a case-control study
https://www.researchgate.net/publication/336047765_D-AMINOLEVULINATE_DEHYDRATASE_AND_GLUTATHIONE_PEROXIDASE_ACTIVITY_IN_ALZHEIMER%27S_DISEASE_A_CASE-CONTROL_STUDY
2020
Risco para doenças cardiovasculares e fatores associados em idosos não institucionalizados com Doença de Alzheimer – https://wdcom.s3.sa-east-1.amazonaws.com/hosting/braspen/journal/2020/journal/out-dez-2020/artigos/07-AO-Risco-para-doencas-cardio.pdf
AVALIAÇÃO DOS POSSÍVEIS EFEITOS NEUROPROTETORES DA CURCUMINA SOBRE O MODELO DE ISQUÊMIA E ESTRESSE OXIDATIVO EM RATOS / EVALUATION OF THE POSSIBLE NEUROPROTECTIVE EFFECTS OF CURCUMINA ON THE MODEL OF ISCHEMIA AND OXIDATIVE STRESS IN RATS – https://brazilianjournals.com/ojs/index.php/BRJD/article/view/16523/13502
Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study – https://seer.ufu.br/index.php/biosciencejournal/article/view/49979
2021
COVID-19: The question of genetic diversity and therapeutic intervention approaches – https://www.scielo.br/j/gmb/a/gdghSWNFyG9qnh9rNGDZyGn/?lang=en
FUNCIONALIDADE NAS ATIVIDADES INSTRUMENTAIS DE VIDA DIÁRIA EM IDOSOS COM DOENÇA DE ALZHEIMER. DESAFIOS: REVISTA INTERDISCIPLINAR DA UNIVERSIDADE FEDERAL DO TOCANTINS – https://sistemas.uft.edu.br/periodicos/index.php/desafios/article/view/9074
Propriedade Intelectual para Inovação: elaboração de uma cartilha sobre inovação tecnológica para profissionais da educação – https://periodicos.ufba.br/index.php/nit/article/view/44916
Technological prospecting of music therapy in Alzheimer’s disease – https://rsdjournal.org/index.php/rsd/article/view/22316
Financial protection of the elderly in light of the general data protection law – https://rsdjournal.org/index.php/rsd/article/view/20973
Lei geral de proteção de dados nº 13.709/2018: apontamentos sobre sua contextualização como marco legal no Brasil – https://rsdjournal.org/index.php/rsd/article/view/20906
Impressora 3D como ferramenta pedagógica: confecção e aplicação das peças neuroanatômicas – https://brazilianjournals.com/index.php/BRJD/article/view/32248?__cf_chl_tk=1IMmzC.zdh3SkZsQep_6ojUsWuw_iMh49Evz93ab83Y-1665061203-0-gaNycGzNCNE
Neuroprotective effects of curcumin and apocynin on spatial memory performance in an animal model of acute neuroinflammation / Efeitos neuroprotetores de curcumina e apocinina sobre o desempenho em memória espacial em modelo animal de neuroinflamação aguda – https://brazilianjournals.com/ojs/index.php/BRJD/article/view/28607
2022
Revista INGI – Indicação Geográfica e Inovação https://ingi.api.org.br/index.php?journal=INGI
Neuroprotective effects of strength training in a neuroinflammatory animal model
https://pubmed.ncbi.nlm.nih.gov/35410134/
Hypothesis on ontogenesis and pathophysiology of Alzheimer’s disease
https://pubmed.ncbi.nlm.nih.gov/36449761/ https://journal.einstein.br/pt-br/article/hypothesis-onontogenesis-and-pathophysiology-of-alzheimers-disease/